Drug induced diabetes treatment,
Steroid induced hyperglycemia and Steroid induced Diabetes
Modeling long-term diabetes and related complications in rats J Pharmacol Toxicol Methods. Mar-Apr ; Epub Nov Gyömrői út Electronic address: erika. DOI: The aims of this study were to establish a model of long-term diabetes with sustained medium scale hyperglycemia and characterize the pathological changes detectable after 4months, with particular respect to dependence on the degree of hyperglycemia.
Methods: Streptozotocin-induced diabetic CFY rats were subjected to four different insulin substitution protocols to achieve different levels of glycemic control Diabetic groups. Eyes were investigated by ophthalmoscopy, kidney function by urine analysis, drug induced diabetes treatment neuropathy by functional tests.
Retinal and renal morphological evaluations were performed by histology, immuno-histochemistry and electron microscopy.
- Protective effects of the novel amine-oxidase inhibitor multi-target drug SZV on streptozotocin-induced beta cell damage and diabetic complications in rats Biomed Pharmacother.
- Modeling long-term diabetes and related complications in rats
- Full size table Experimental design A To investigate the effect of DDW on metabolic changes occur in diabetes, diabetic and control rats were divided into two main groups: half of the animals were given DDW 25 ppm Dand the other half received normal tap water ppm Dboth provided ad libitum.
Discussion: We established a treatment protocol in rats enabling complex investigation of diabetic retinopathy, nephropathy and neuropathy on a long-term period. Clearly hyperglycemic dependent parameters of these complications serve as good outcome measures for preclinical trials.
Our results provide a useful basis for designing studies for testing preventative treatments as well as other translational medical research in this field.
Keywords: Anterior segment neovascularization; Chronic model; Cold allodynia; Diabetic nephropathy; Diabetic neuropathy; Diabetic retinopathy; Drug development; Insulin implant; Preclinical model; Streptozotocin. Copyright © Elsevier Inc. All rights reserved. Publication types.